New perspectives of post-GWAS analyses: From markers to causal genes for more precise crop breeding
Ivana Kaňovská, Jana Biová and Mária Škrabišová
28.01.2025
Crop breeding advancement is hindered by the imperfection of methods to reveal genes underlying key traits. Genome-wide Association Study (GWAS) is one such method, identifying genomic regions linked to phenotypes. Post-GWAS analyses predict candidate genes and assist in causative mutation (CM) recognition. Here, we assess post-GWAS approaches, address limitations in omics data integration and stress the importance of evaluating associated variants within a broader context of publicly available datasets. Recent advances in bioinformatics tools and genomic strategies for CM identification and allelic variation exploration are reviewed. We discuss the role of markers and marker panel development for more precise breeding. Finally, we highlight the perspectives and challenges of GWAS-based CM prediction for complex quantitative traits.
Downloads
About this article
Ivana Kaňovská, Jana Biová and Mária Škrabišová
Legume Generation (Boosting innovation in breeding for the next generation of legume crops for Europe) has received funding from the European Union through Horizon Europe under grant agreement No 101081329 and co-funding from UK Research and Innovation (UKRI) from the UK government’s Horizon Europe funding guarantee. It also receives support from the governments of Switzerland and New Zealand.
For matters related to publisher, citation and copyright, please refer to the original article.
The content is solely the responsibility of the authors. No warranties, expressed or implied, are made with respect to the information provided. Information relating to the use of plant protection products (pesticides) must be checked against the product label or other sources of product registration information.
0 Comments